Implemented DomainRepresentationPredictor in NanoVirDx using Histo 0.0.127’s public load_models and process_scan boundary.
Added a flattened, packaged Histo v2.0 fine28/local configuration because the Histo wheel omits its repository-level Hydra config. Callers can still supply an existing PipelineSettings.
Extended DomainRepresentationBatch and vxData downloads with the required nuclei segmentation artifact, and added aligned WSI/mask validation.
Inspected origin/cedrik/fk-fix in DiffSim and confirmed that fine28 is the current Histo v2 taxonomy: 28 base classes plus 12 graded classes with sparse IDs 128-139.
Ported Cedrik’s nine-compartment mapping and tissue parameters into NanoVirDx. Added a narrow compatibility loader for DiffSim 0.1.100, which does not understand Histo v2 region_ids.
Validated the adapter using a mocked Histo boundary. Validated a complete synthetic 40-class Histo v2 domain through T2, high-b DWI, and ADC simulation on Metal with finite outputs.
Built the NanoVirDx wheel and confirmed that the vendored YAML is packaged. Ruff, Pyright, compileall, module boundaries, and diff checks passed.
Committed and pushed mono commit d78b25e8 to origin/fk/nanovirdx.
Lessons Learned: Pitfalls
DiffSim 0.1.100 validates a positional mapping against 40 region names but then indexes it with sparse labels up to 139. A 40-entry mapping therefore passes validation and fails during remapping; a 140-entry mapping fails validation.
Histo 0.0.127 contains the domain-representation implementation but does not package its required configuration. A source-relative Hydra path is not a valid installed-package interface.
Running Pyright from DiffSim’s environment initially produced false missing-import errors. The NanoVirDx interpreter and Histo source path were needed for the relevant result.
Lessons Learned: Improvements
Publish Cedrik’s name/region_ids mapping support in DiffSim, then remove NanoVirDx’s _domain_from_histo_v2 compatibility loader and return to the public domain_from_histo API.
Package Histo’s supported v2 settings and expose a default-settings helper, then delete NanoVirDx’s vendored YAML.
Add an Nx project and a small platform-independent adapter test target for NanoVirDx so its lazy Linux-only integrations are exercised in CI.
