---
title: "inverse (ve2e)"
description: "Deep inverse models that infer prostate-cancer disease state (csPCa, ISUP grade, lesion location) from bi-parametric MRI."
image: "https://docs.virdx.dev/img/virdx-social-card.png"
---

> Documentation Index
> Fetch the complete documentation index at: https://docs.virdx.dev/llms.txt
> Use this file to discover all available pages before exploring further.

# inverse (ve2e)

Goal: accurately infer disease state from bi-parametric MRI using deep
inverse models. Filed monthly reports use the tag/name `ve2e` — treat
`ve2e` and `inverse` as the same workstream.

## Status at a glance (as of the last filed report, March 2026)

- `vx1` (DINOv3 ViT encoder, separate classification + segmentation heads)
  held **1st place** on the PI-CAI Open Tuning Leaderboard (0.935 AUROC,
  0.774 AP) for patient-level csPCa classification; work has since moved to
  lesion-level detection/calibration and 4-class ISUP grading.
- **FlexDINO**: a single model, operating at quadrant/slice/patient field of
  view via quadrant-masked self-attention + gated attention-based MIL
  aggregation — built to let simulated (`diffsim`) data feed training at
  sub-patient granularity.
- Engineering: the data-platform-based training pipeline is integrated up to
  preloading (Argo-orchestrated), not yet used for production training; an
  autonomous LLM-driven experiment-automation stack (logger + structured
  research context + closed-loop protocol) was stood up, initially
  targeting late-fusion DINO hyperparameter search.
- **SDK migration**: per the June 2026 engineering report, `ve2e` was the
  first downstream consumer to migrate off `vxp_client` onto `vxdata-sdk`
  1.0 (2026-06-19) — see
  [vxdata-sdk-and-local-dev.md](/knowledge/wiki/workstreams/infrastructure/sops/vxdata-sdk-and-schema-model)
  for the current client API.

## Source material

- [sources/monthly-reports/](https://github.com/virdx/knowledge/blob/main/sources/monthly-reports/index.md) —
  filed as `<MM>-2026_ve2e.md`. Jan 2026 is an explicit "no report filed"
  stub; Feb 2026 has no file at all (unlike diffsim/engineering, no explicit
  gap marker exists for `ve2e` Feb — treat as an unknown gap); no report has
  been filed since March.

No dedicated `projects/` or `sops/` subdirectories exist yet for this
workstream — add them here as inverse/ve2e work gets synthesized from
`inbox/`.

Source: https://docs.virdx.dev/knowledge/wiki/workstreams/inverse/index.mdx